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The animal literature is instructive here

doi: 10.1007/s11357-010-9158-4

Classically, this effect is attributed to the fact that the phosphate form of selenium, which is essential for some steps of the gene transcription for Se-GSH-Px synthesis, would be more readily available from selenite than from selenomethionine (Yasumoto et al., 1979

In addition, decreasing nuclear Srebf1 levels by deletion of Scap , which is necessary to generate nuclear isoforms of Srebf1 , protected against hepatic steatosis in ob/ob mice and mice under HFDs (55)

12 Alanine scanning mutagenesis has confirmed the importance of Phe23 and 25, Tyr31, Arg36, Arg 37, Val44, and Tyr60, the residues that compose the binding site